Atlanta Braves vs Washington Nationals prediction — 2026-04-22 • First pitch: 6:45 PM ET
Odds-158
Confidence0.581 (data points: 18.887/23.887)
PitchingDidier Fuentes vs Zack Littell
VenueNationals Park
Call it a value-and-fit play: Atlanta Braves at -158. The market note is Moneyline moved from -145 to -138 (+7), away from the pick side, and the starting matchup (Didier Fuentes vs Zack Littell) keeps the original side intact.
Atlanta Braves is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Washington Nationals can absolutely swing this game at Nationals Park, but over nine innings the steadier path still points to Atlanta Braves, so the stance does not change.
Expanded game context
Weather: 75.6°F, Wind 9.6 mph S (out to CF), Humidity 40%, P.O.P. 3% (Open-Meteo fallback)
Umpire Crew: Home Plate: Brian O'Nora; First Base: Chris Segal; Second Base: Erich Bacchus; Third Base: Laz Diaz
Atlanta Braves Injuries: Aaron Bummer (Active), Austin Riley (Active), Bryce Elder (Active), Chris Sale (Active), Didier Fuentes (Active), Dominic Smith (Active), Drake Baldwin (Active), Dylan Dodd (Active)
Washington Nationals Injuries: Brad Lord (Active), Brady House (Active), CJ Abrams (Active), Cade Cavalli (Active), Cionel Pérez (Active), Clayton Beeter (Active), Curtis Mead (Active), Daylen Lile (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Atlanta Braves: Compared with last 5 games, today's announced lineup shares 7.4/9 starters on average. in stable-lineup comps (≥8 shared), Atlanta Braves went 1-1. Washington Nationals: Compared with last 5 games, today's announced lineup shares 6.2/9 starters on average. In higher-turnover comps (≤6 shared), Washington Nationals went 2-1.
Line Movement: Moneyline moved from -145 to -138 (+7), away from the pick side.
Pick 2
Los Angeles Dodgers over San Francisco Giants
In Progress
Los Angeles Dodgers vs San Francisco Giants prediction — 2026-04-22 • First pitch: 9:45 PM ET
Odds-203
Confidence0.578 (data points: 19.102/24.217)
PitchingShohei Ohtani vs Tyler Mahle
VenueOracle Park
The pregame case is straightforward: Los Angeles Dodgers at -203. The market note is Moneyline moved from -205 to -159 (+46), away from the pick side, and the starting matchup (Shohei Ohtani vs Tyler Mahle) keeps the original side intact.
Los Angeles Dodgers is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
San Francisco Giants can absolutely swing this game at Oracle Park, but over nine innings the steadier path still points to Los Angeles Dodgers, so the stance does not change.
Umpire Crew: Home Plate: Jordan Baker; First Base: Rob Drake; Second Base: Stu Scheurwater; Third Base: Junior Valentine
Los Angeles Dodgers Injuries: Alex Call (Active), Alex Freeland (Active), Alex Vesia (Active), Andy Pages (Active), Blake Treinen (Active), Dalton Rushing (Active), Edgardo Henriquez (Active), Emmet Sheehan (Active)
San Francisco Giants Injuries: Adrian Houser (Active), Blade Tidwell (Active), Caleb Kilian (Active), Casey Schmitt (Active), Christian Koss (Active), Drew Gilbert (Active), Eric Haase (Active), Erik Miller (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Los Angeles Dodgers: Compared with last 5 games, today's announced lineup shares 6.6/9 starters on average. In higher-turnover comps (≤6 shared), Los Angeles Dodgers went 1-1. San Francisco Giants: Compared with last 5 games, today's announced lineup shares 8.0/9 starters on average. in stable-lineup comps (≥8 shared), San Francisco Giants went 4-0.
Line Movement: Moneyline moved from -205 to -159 (+46), away from the pick side.
Pick 3
Kansas City Royals over Baltimore Orioles
LOSS
Kansas City Royals vs Baltimore Orioles prediction — 2026-04-22 • First pitch: 2:10 PM ET
Odds-130
Confidence0.489 (data points: 17.477/23.477)
PitchingMichael Wacha vs Chris Bassitt
VenueKauffman Stadium
This number is playable as listed: Kansas City Royals at -130. The market note is Line movement unavailable, and the starting matchup (Michael Wacha vs Chris Bassitt) keeps the original side intact.
Kansas City Royals is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Baltimore Orioles can absolutely swing this game at Kauffman Stadium, but over nine innings the steadier path still points to Kansas City Royals, so the stance does not change.
Umpire Crew: Home Plate: Adrian Johnson; First Base: Paul Clemons; Second Base: Quinn Wolcott; Third Base: Brock Ballou
Kansas City Royals Injuries: Alex Lange (Active), Bobby Witt Jr. (Active), Carter Jensen (Active), Cole Ragans (Active), Daniel Lynch IV (Active), Eli Morgan (Active), Elias Díaz (Active), Isaac Collins (Active)
Baltimore Orioles Injuries: Adley Rutschman (Active), Albert Suárez (Active), Anthony Nunez (Active), Blaze Alexander (Active), Cameron Foster (Active), Chris Bassitt (Active), Coby Mayo (Active), Colton Cowser (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Kansas City Royals: Compared with last 5 games, today's announced lineup shares 6.6/9 starters on average. In higher-turnover comps (≤6 shared), Kansas City Royals went 0-3. Baltimore Orioles: Compared with last 5 games, today's announced lineup shares 7.6/9 starters on average. in stable-lineup comps (≥8 shared), Baltimore Orioles went 0-2.
Line Movement: Line movement unavailable.
Pick 4
Los Angeles Angels over Toronto Blue Jays
WIN
Los Angeles Angels vs Toronto Blue Jays prediction — 2026-04-22 • First pitch: 3:07 PM ET
From first pitch onward, the cleaner side is: Los Angeles Angels at -149. The market note is Line movement unavailable, and the starting matchup (José Soriano vs Eric Lauer) keeps the original side intact.
Los Angeles Angels is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Toronto Blue Jays can absolutely swing this game at Angel Stadium, but over nine innings the steadier path still points to Los Angeles Angels, so the stance does not change.
Umpire Crew: Home Plate: Chad Whitson; First Base: Bill Miller; Second Base: Brian Walsh; Third Base: Chad Fairchild
Los Angeles Angels Injuries: Adam Frazier (Active), Brent Suter (Active), Bryce Teodosio (Active), Chase Silseth (Active), Drew Pomeranz (Active), Jack Kochanowicz (Active), Jo Adell (Active), Jordan Romano (Active)
Toronto Blue Jays Injuries: Andrés Giménez (Active), Brandon Valenzuela (Active), Braydon Fisher (Active), Daulton Varsho (Active), Davis Schneider (Active), Dylan Cease (Active), Eloy Jiménez (Active), Eric Lauer (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Los Angeles Angels: Compared with last 5 games, today's announced lineup shares 6.8/9 starters on average. In higher-turnover comps (≤6 shared), Los Angeles Angels went 0-2. Toronto Blue Jays: Compared with last 5 games, today's announced lineup shares 6.8/9 starters on average. In higher-turnover comps (≤6 shared), Toronto Blue Jays went 2-0; in stable-lineup comps (≥8 shared), Toronto Blue Jays went 1-1.
Line Movement: Line movement unavailable.
Pick 5
Minnesota Twins over New York Mets
LOSS
Minnesota Twins vs New York Mets prediction — 2026-04-22 • First pitch: 7:10 PM ET
Odds+134
Confidence0.258 (data points: 9.296/14.78)
PitchingConnor Prielipp vs Clay Holmes
VenueCiti Field
The board gives us a clear side: Minnesota Twins at +134. The market note is Moneyline moved from 134 to -118 (-252), toward the pick side, and the starting matchup (Connor Prielipp vs Clay Holmes) keeps the original side intact.
Minnesota Twins is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
New York Mets can absolutely swing this game at Citi Field, but over nine innings the steadier path still points to Minnesota Twins, so the stance does not change.
Expanded game context
Weather: 51.3°F, Wind 3.6 mph ENE (in from LF), Humidity 74%, P.O.P. 1% (Open-Meteo fallback)
Umpire Crew: Home Plate: Ryan Wills; First Base: Lance Barksdale; Second Base: Will Little; Third Base: Ryan Additon
Minnesota Twins Injuries: Andrew Morris (Active), Anthony Banda (Active), Austin Martin (Active), Bailey Ober (Active), Brooks Lee (Active), Byron Buxton (Active), Cole Sands (Active), Connor Prielipp (Active)
New York Mets Injuries: Austin Warren (Active), Bo Bichette (Active), Brett Baty (Active), Brooks Raley (Active), Carson Benge (Active), Clay Holmes (Active), Craig Kimbrel (Active), David Peterson (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Minnesota Twins: Compared with last 5 games, today's announced lineup shares 5.4/9 starters on average. In higher-turnover comps (≤6 shared), Minnesota Twins went 1-4. New York Mets: Compared with last 5 games, today's announced lineup shares 7.2/9 starters on average. in stable-lineup comps (≥8 shared), New York Mets went 0-2.
Line Movement: Moneyline moved from 134 to -118 (-252), toward the pick side.
Pick 6
New York Yankees over Boston Red Sox
WIN
New York Yankees vs Boston Red Sox prediction — 2026-04-22 • First pitch: 6:45 PM ET
Odds-130
Confidence0.252 (data points: 15.217/24.318)
PitchingMax Fried vs Ranger Suarez
VenueFenway Park
This matchup leans one way before the noise starts: New York Yankees at -130. The market note is Moneyline moved from -141 to -155 (-14), toward the pick side, and the starting matchup (Max Fried vs Ranger Suarez) keeps the original side intact.
New York Yankees is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Boston Red Sox can absolutely swing this game at Fenway Park, but over nine innings the steadier path still points to New York Yankees, so the stance does not change.
Expanded game context
Weather: 45.3°F, Wind 7.6 mph S (out to LF), Humidity 80%, P.O.P. 1% (Open-Meteo fallback)
Umpire Crew: Home Plate: Todd Tichenor; First Base: John Libka; Second Base: Clint Vondrak; Third Base: Austin Jones
New York Yankees Injuries: Aaron Judge (Active), Amed Rosario (Active), Angel Chivilli (Active), Austin Wells (Active), Ben Rice (Active), Brent Headrick (Active), Cam Schlittler (Active), Camilo Doval (Active)
Boston Red Sox Injuries: Andruw Monasterio (Active), Aroldis Chapman (Active), Brayan Bello (Active), Caleb Durbin (Active), Carlos Narváez (Active), Ceddanne Rafaela (Active), Connelly Early (Active), Connor Wong (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: New York Yankees: Compared with last 5 games, today's announced lineup shares 6.0/9 starters on average. In higher-turnover comps (≤6 shared), New York Yankees went 4-1. Boston Red Sox: Compared with last 5 games, today's announced lineup shares 6.4/9 starters on average. In higher-turnover comps (≤6 shared), Boston Red Sox went 2-2.
Line Movement: Moneyline moved from -141 to -155 (-14), toward the pick side.
Pick 7
Arizona Diamondbacks over Chicago White Sox
In Progress
Arizona Diamondbacks vs Chicago White Sox prediction — 2026-04-22 • First pitch: 9:40 PM ET
Odds-153
Confidence0.222 (data points: 15.719/25.719)
PitchingEduardo Rodriguez vs Anthony Kay
VenueChase Field
The handicap lands here: Arizona Diamondbacks at -153. The market note is Moneyline unchanged at -152, and the starting matchup (Eduardo Rodriguez vs Anthony Kay) keeps the original side intact.
Arizona Diamondbacks is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Chicago White Sox can absolutely swing this game at Chase Field, but over nine innings the steadier path still points to Arizona Diamondbacks, so the stance does not change.
Expanded game context
Weather: Dome/retractable roof environment — external wind conditions not applicable.
Umpire Crew: Home Plate: Jeremie Rehak; First Base: Cory Blaser; Second Base: Adam Beck; Third Base: Doug Eddings
Arizona Diamondbacks Injuries: Adrian Del Castillo (Active), Alek Thomas (Active), Andrew Hoffmann (Active), Aramis Garcia (Active), Brandon Pfaadt (Active), Corbin Carroll (Active), Eduardo Rodriguez (Active), Geraldo Perdomo (Active)
Chicago White Sox Injuries: Andrew Benintendi (Active), Anthony Kay (Active), Bryan Hudson (Active), Chase Meidroth (Active), Colson Montgomery (Active), Davis Martin (Active), Derek Hill (Active), Edgar Quero (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Arizona Diamondbacks: Compared with last 5 games, today's announced lineup shares 6.8/9 starters on average. Chicago White Sox: Compared with last 5 games, today's announced lineup shares 6.2/9 starters on average. In higher-turnover comps (≤6 shared), Chicago White Sox went 1-2.
Line Movement: Moneyline unchanged at -152.
Pick 8
Tampa Bay Rays over Cincinnati Reds
WIN
Tampa Bay Rays vs Cincinnati Reds prediction — 2026-04-22 • First pitch: 1:10 PM ET
Odds-139
Confidence0.162 (data points: 13.859/23.859)
PitchingNick Martinez vs Brandon Williamson
VenueTropicana Field
The market is offering a workable angle: Tampa Bay Rays at -139. The market note is Line movement unavailable, and the starting matchup (Nick Martinez vs Brandon Williamson) keeps the original side intact.
Tampa Bay Rays is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Cincinnati Reds can absolutely swing this game at Tropicana Field, but over nine innings the steadier path still points to Tampa Bay Rays, so the stance does not change.
Expanded game context
Weather: Dome/retractable roof environment — external wind conditions not applicable.
Umpire Crew: Home Plate: Ryan Blakney; First Base: Nick Mahrley; Second Base: Marvin Hudson; Third Base: Tripp Gibson
Tampa Bay Rays Injuries: Ben Williamson (Active), Bryan Baker (Active), Cedric Mullins (Active), Chandler Simpson (Active), Cole Sulser (Active), Drew Rasmussen (Active), Griffin Jax (Active), Hunter Bigge (Active)
Cincinnati Reds Injuries: Andrew Abbott (Active), Brady Singer (Active), Brandon Williamson (Active), Brock Burke (Active), Chase Burns (Active), Connor Phillips (Active), Dane Myers (Active), Elly De La Cruz (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Tampa Bay Rays: Compared with last 5 games, today's announced lineup shares 6.8/9 starters on average. In higher-turnover comps (≤6 shared), Tampa Bay Rays went 0-2. Cincinnati Reds: Compared with last 5 games, today's announced lineup shares 6.0/9 starters on average. In higher-turnover comps (≤6 shared), Cincinnati Reds went 4-0.
Line Movement: Line movement unavailable.
Pick 9
Pittsburgh Pirates over Texas Rangers
WIN
Pittsburgh Pirates vs Texas Rangers prediction — 2026-04-22 • First pitch: 8:05 PM ET
Call it a value-and-fit play: Pittsburgh Pirates at -113. The market note is Moneyline moved from -109 to 135 (+244), away from the pick side, and the starting matchup (Braxton Ashcraft vs Jack Leiter) keeps the original side intact.
Pittsburgh Pirates is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Texas Rangers can absolutely swing this game at Globe Life Field, but over nine innings the steadier path still points to Pittsburgh Pirates, so the stance does not change.
Expanded game context
Weather: Dome/retractable roof environment — external wind conditions not applicable.
Umpire Crew: Home Plate: Shane Livensparger; First Base: Dan Merzel; Second Base: Dan Bellino; Third Base: Mark Ripperger
Pittsburgh Pirates Injuries: Billy Cook (Active), Brandon Lowe (Active), Braxton Ashcraft (Active), Bryan Reynolds (Active), Bubba Chandler (Active), Carmen Mlodzinski (Active), Dennis Santana (Active), Evan Sisk (Active)
Texas Rangers Injuries: Alejandro Osuna (Active), Andrew McCutchen (Active), Brandon Nimmo (Active), Cal Quantrill (Active), Cole Winn (Active), Corey Seager (Active), Danny Jansen (Active), Evan Carter (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Pittsburgh Pirates: Compared with last 5 games, today's announced lineup shares 6.8/9 starters on average. In higher-turnover comps (≤6 shared), Pittsburgh Pirates went 1-1. Texas Rangers: Compared with last 5 games, today's announced lineup shares 7.6/9 starters on average. in stable-lineup comps (≥8 shared), Texas Rangers went 2-2.
Line Movement: Moneyline moved from -109 to 135 (+244), away from the pick side.
Pick 10
Seattle Mariners over Athletics
WIN
Seattle Mariners vs Athletics prediction — 2026-04-22 • First pitch: 4:10 PM ET
Odds-184
Confidence0.148 (data points: 16.38/28.534)
PitchingLogan Gilbert vs Aaron Civale
VenueT-Mobile Park
The pregame case is straightforward: Seattle Mariners at -184. The market note is Line movement unavailable, and the starting matchup (Logan Gilbert vs Aaron Civale) keeps the original side intact.
Seattle Mariners is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Athletics can absolutely swing this game at T-Mobile Park, but over nine innings the steadier path still points to Seattle Mariners, so the stance does not change.
Expanded game context
Weather: Dome/retractable roof environment — external wind conditions not applicable.
Umpire Crew: Home Plate: Alfonso Márquez; First Base: Willie Traynor; Second Base: Mike Estabrook; Third Base: Malachi Moore
Seattle Mariners Injuries: Alex Hoppe (Active), Andrés Muñoz (Active), Bryan Woo (Active), Cal Raleigh (Active), Cole Wilcox (Active), Cole Young (Active), Connor Joe (Active), Cooper Criswell (Active)
Athletics Injuries: Aaron Civale (Active), Andy Ibáñez (Active), Austin Wynns (Active), Brady Basso (Active), Carlos Cortes (Active), Colby Thomas (Active), Darell Hernaiz (Active), Hogan Harris (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Seattle Mariners: Compared with last 5 games, today's announced lineup shares 7.8/9 starters on average. in stable-lineup comps (≥8 shared), Seattle Mariners went 1-2. Athletics: Compared with last 5 games, today's announced lineup shares 7.2/9 starters on average. In higher-turnover comps (≤6 shared), Athletics went 1-1; in stable-lineup comps (≥8 shared), Athletics went 2-1.
Line Movement: Line movement unavailable.
Pick 11
San Diego Padres over Colorado Rockies
In Progress
San Diego Padres vs Colorado Rockies prediction — 2026-04-22 • First pitch: 8:40 PM ET
Odds-157
Confidence0.089 (data points: 12.538/23.024)
PitchingWalker Buehler vs Tomoyuki Sugano
VenueCoors Field
This number is playable as listed: San Diego Padres at -157. The market note is Moneyline moved from -159 to -156 (+3), away from the pick side, and the starting matchup (Walker Buehler vs Tomoyuki Sugano) keeps the original side intact.
San Diego Padres is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Colorado Rockies can absolutely swing this game at Coors Field, but over nine innings the steadier path still points to San Diego Padres, so the stance does not change.
Umpire Crew: Home Plate: Alan Porter; First Base: Roberto Ortiz; Second Base: Jim Wolf; Third Base: Alex MacKay
San Diego Padres Injuries: Adrian Morejon (Active), Bradgley Rodriguez (Active), Bryce Johnson (Active), David Morgan (Active), Fernando Tatis Jr. (Active), Freddy Fermin (Active), Gavin Sheets (Active), Germán Márquez (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: San Diego Padres: Compared with last 5 games, today's announced lineup shares 6.8/9 starters on average. In higher-turnover comps (≤6 shared), San Diego Padres went 2-0. Colorado Rockies: Compared with last 5 games, today's announced lineup shares 6.2/9 starters on average. In higher-turnover comps (≤6 shared), Colorado Rockies went 1-2.
Line Movement: Moneyline moved from -159 to -156 (+3), away from the pick side.
Pick 12
Houston Astros over Cleveland Guardians
WIN
Houston Astros vs Cleveland Guardians prediction — 2026-04-22 • First pitch: 1:10 PM ET
Odds+139
Confidence0.074 (data points: 12.881/23.982)
PitchingPeter Lambert vs Tanner Bibee
VenueProgressive Field
From first pitch onward, the cleaner side is: Houston Astros at +139. The market note is Line movement unavailable, and the starting matchup (Peter Lambert vs Tanner Bibee) keeps the original side intact.
Houston Astros is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Cleveland Guardians can absolutely swing this game at Progressive Field, but over nine innings the steadier path still points to Houston Astros, so the stance does not change.
Expanded game context
Weather: 61.5°F, Wind 5.4 mph NW (in from RF), Humidity 82%, P.O.P. 0% (Open-Meteo fallback)
Umpire Crew: Home Plate: Alex Tosi; First Base: Jansen Visconti; Second Base: Andy Fletcher; Third Base: Derek Thomas
Houston Astros Injuries: AJ Blubaugh (Active), Braden Shewmake (Active), Brice Matthews (Active), Bryan Abreu (Active), Bryan King (Active), Cam Smith (Active), Carlos Correa (Active), Christian Vázquez (Active)
Cleveland Guardians Injuries: Angel Martínez (Active), Austin Hedges (Active), Bo Naylor (Active), Brayan Rocchio (Active), Cade Smith (Active), Chase DeLauter (Active), Connor Brogdon (Active), Daniel Schneemann (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Houston Astros: Compared with last 5 games, today's announced lineup shares 7.0/9 starters on average. Cleveland Guardians: Compared with last 5 games, today's announced lineup shares 7.2/9 starters on average. in stable-lineup comps (≥8 shared), Cleveland Guardians went 1-2.
Line Movement: Line movement unavailable.
Pick 13
Detroit Tigers over Milwaukee Brewers
WIN
Detroit Tigers vs Milwaukee Brewers prediction — 2026-04-22 • First pitch: 6:40 PM ET
Odds-133
Confidence0.068 (data points: 12.858/24.083)
PitchingCasey Mize vs DL Hall
VenueComerica Park
The board gives us a clear side: Detroit Tigers at -133. The market note is Moneyline moved from -133 to -218 (-85), toward the pick side, and the starting matchup (Casey Mize vs DL Hall) keeps the original side intact.
Detroit Tigers is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Milwaukee Brewers can absolutely swing this game at Comerica Park, but over nine innings the steadier path still points to Detroit Tigers, so the stance does not change.
Expanded game context
Weather: 70.3°F, Wind 9.3 mph ENE (in from RF), Humidity 49%, P.O.P. 2% (Open-Meteo fallback)
Umpire Crew: Home Plate: Mike Muchlinski; First Base: Gabe Morales; Second Base: Dexter Kelley; Third Base: Emil Jimenez
Detroit Tigers Injuries: Brant Hurter (Active), Burch Smith (Active), Casey Mize (Active), Colt Keith (Active), Connor Seabold (Active), Dillon Dingler (Active), Drew Anderson (Active), Framber Valdez (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Detroit Tigers: Compared with last 5 games, today's announced lineup shares 6.4/9 starters on average. In higher-turnover comps (≤6 shared), Detroit Tigers went 1-2. Milwaukee Brewers: Compared with last 5 games, today's announced lineup shares 7.4/9 starters on average. in stable-lineup comps (≥8 shared), Milwaukee Brewers went 2-0.
Line Movement: Moneyline moved from -133 to -218 (-85), toward the pick side.
Pick 14
Miami Marlins over St. Louis Cardinals
WIN
Miami Marlins vs St. Louis Cardinals prediction — 2026-04-22 • First pitch: 12:10 PM ET
Odds-142
Confidence0.054 (data points: 14.477/27.477)
PitchingJanson Junk vs Kyle Leahy
VenueloanDepot park
This matchup leans one way before the noise starts: Miami Marlins at -142. The market note is Line movement unavailable, and the starting matchup (Janson Junk vs Kyle Leahy) keeps the original side intact.
Miami Marlins is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
St. Louis Cardinals can absolutely swing this game at loanDepot park, but over nine innings the steadier path still points to Miami Marlins, so the stance does not change.
Expanded game context
Weather: Dome/retractable roof environment — external wind conditions not applicable.
Umpire Crew: Home Plate: Jacob Metz; First Base: Tom Hanahan; Second Base: Scott Barry; Third Base: Manny Gonzalez
Miami Marlins Injuries: Agustín Ramírez (Active), Andrew Nardi (Active), Anthony Bender (Active), Austin Slater (Active), Calvin Faucher (Active), Chris Paddack (Active), Connor Norby (Active), Eury Pérez (Active)
St. Louis Cardinals Injuries: Alec Burleson (Active), Andre Pallante (Active), Dustin May (Active), George Soriano (Active), Gordon Graceffo (Active), Iván Herrera (Active), JJ Wetherholt (Active), JoJo Romero (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Miami Marlins: Compared with last 5 games, today's announced lineup shares 7.0/9 starters on average. St. Louis Cardinals: Compared with last 5 games, today's announced lineup shares 6.0/9 starters on average. In higher-turnover comps (≤6 shared), St. Louis Cardinals went 4-1.
Line Movement: Line movement unavailable.
Pick 15
Philadelphia Phillies over Chicago Cubs
LOSS
Philadelphia Phillies vs Chicago Cubs prediction — 2026-04-22 • First pitch: 7:40 PM ET
Odds+161
Confidence0.025 (data points: 12.231/23.859)
PitchingKyle Backhus vs Matthew Boyd
VenueWrigley Field
The handicap lands here: Philadelphia Phillies at +161. The market note is Moneyline moved from 145 to -126 (-271), toward the pick side, and the starting matchup (Kyle Backhus vs Matthew Boyd) keeps the original side intact.
Philadelphia Phillies is in the away role, and that matters because this lineup can create pressure without needing one big inning. Both starting lineups were announced at publish time.
Chicago Cubs can absolutely swing this game at Wrigley Field, but over nine innings the steadier path still points to Philadelphia Phillies, so the stance does not change.
Expanded game context
Weather: 53.4°F, Wind 7.9 mph NNE (in from CF), Humidity 69%, P.O.P. 0% (Open-Meteo fallback)
Umpire Crew: Home Plate: John Bacon; First Base: Hunter Wendelstedt; Second Base: Edwin Moscoso; Third Base: Vic Carapazza
Philadelphia Phillies Injuries: Aaron Nola (Active), Adolis García (Active), Alan Rangel (Active), Alec Bohm (Active), Andrew Painter (Active), Brad Keller (Active), Brandon Marsh (Active), Bryce Harper (Active)
Chicago Cubs Injuries: Alex Bregman (Active), Ben Brown (Active), Caleb Thielbar (Active), Carson Kelly (Active), Colin Rea (Active), Corbin Martin (Active), Dansby Swanson (Active), Edward Cabrera (Active)
Starting Lineups: Both starting lineups were announced at publish time.
Lineup Change Impact: Philadelphia Phillies: Compared with last 5 games, today's announced lineup shares 7.0/9 starters on average. Chicago Cubs: Compared with last 5 games, today's announced lineup shares 7.2/9 starters on average. in stable-lineup comps (≥8 shared), Chicago Cubs went 2-0.
Line Movement: Moneyline moved from 145 to -126 (-271), toward the pick side.